GcMAF (Gc protein-derived macrophage activating factor) is a Vitamin D binding protein naturally found in the human body. The function of this protein is to activate, regulate and expand macrophages. Macrophages (M1 and M2) are involved in tissue repair and stimulate immune cells to respond to pathogens; attacking foreign substances, infectious microbes and cancer cells through destruction and ingestion.
This activity can be seen in this video.
An enzyme in the human body, known as Nagalase, has been found to deactivate macrophage activity, thus suppressing the immune system. The Nagalase enzyme is released by tumor and virus-infected cells and has been reported to accumulate in the serum of cancer and HIV patients. High Nagalase levels have also been found in many autistic children.
Research has found that immune system dysfunction may play a role in many, if not all, patients with autism. One recent study found significantly lower levels of cytokines in the plasma of children with autism disorder compared to that of healthy children. Cytokines are molecules that aid communication between cells for immune responses, stimulating the movement of cells toward sites of inflammation, infection and trauma.
GcMAF has been championed by Dr. Jeff Bradstreet to treat autism. During his treatment, he has found that 85% of all children improve, 15% recover and another 15% see no difference. It has been found that GcMAF also reduces high Nagalase levels.
GcMAF is a naturally occurring protein, generated under normal conditions by a fully functioning immune system. It is extracted from donor blood sourced serum gcprotein, screened with FDA approved tests for HBsAg (hepatitis B surface antigen), HCV (Hepatitis C), HBc (Hepatitis B core protein), and HIV 1 & 2. The final product is also sterilized by passing through a 0.22-µm filter, and potential endotoxins are removed using a detox gel.
There are currently several ways to treat with GcMAF, which is known as immunostimulatory therapy.
1. GcMAF (injectable)
One strength injectable. Comes in a 2.2mL vile.
Yogurt enriched in powerful immuno-stimulating molecules including GcMAF. This product must be made/cultured at home, using bovine milk and colostrum. GcMAF that contained in the yogurt is bovine in nature, which is about 86% compatible with human GcMAF. Mixed results have been seen with this product and early lab tests were unable to pinpoint the GcMAF in the product. As a probiotic, improved gut flora also improves immune system action.
3. GOleic (sublingual drops)
The GOleic is a sublingual gcmaf, combined with oleic acid. Oleic acid (a component of olive oil) is known to enhance sublingual absorption. In addition, it is believed that the Gc protein binds to fatty acids, making it more effective in transport to the Vitamin D receptor.
Oleic acid can also be consumed in the diet. It can be supplemented, with olive oil, coconut oil or MCT oil etc for those who wish to use the injectable version or MAFActive version (below).
MAFACtive is a homeopathic-strength dilution of the vitamin D binding protein.
It was previously available in a spray or dropper and tasted like salt water. It came in 2 different strengths (220 and 880) allowing lower dosing suitable for autism, CFS and other ailments where an abrupt stimulation of the immune system might give rise to a healing crisis. New users of MAFActive were suggested to try the lower dose first.
MAFActive was launched to a small group, to see if the delivery via sublingual would be effective. MAFActive was proving very effective for autism – ‘All of the initial group giving feedback on MAFActive Spray or Drops saw gains, from just 1% up to 45% improvement in the ATEC score, averaging at around 23% improvement. No one reported a deterioration using the ATEC score.’
5. Hygiene and Beauty Products – The massage cream is used as a lymphatic massage. The protein is absorbed into the skin and has given the same outcome as being absorbed sublingually.
Which one was better?
There has been no effective comparative study of the different types of GcMAF. A GcMAF research initiative was set up to allow a comparison of the types, and welcomes feedback from any GcMAF user, including injectables and GOleic.
Dosage of each medium typically depends on body weight and the individual response of each person. Injections typically start at .01mL and is increased every couple of times, depending on the tolerance of the individual.
Vitamin D3 is typically supplemented in addition to GcMAF. It is suggested that Vitamin D3 be taken with Vitamin K2. D3/K2
The TRUE Recommended Daily Allowance of Vitamin D should be about 9000 IU per day. The Institute of Medicine originally recommended 600 IU, which has been determined to have been gravely miscalculated.
Some parents have reported increased urination as side effect, which could be considered a detox mechanism.
Where/how to purchase
Bravo Probiotic – $439 US + $66 shipping US.
**The manufacturing of MAFactive products has been interrupted due to questions regarding compliance and registration issues. The problems are not involving the U.S. but will affect distribution. Until further notice the MAFactive creams and toothpaste are not available. Please consider helping Lesley Hutchings who is facing serious charges in connection with making “illegal medications”, in France, where her home has been raided.**
Saisei Lab – High dose GcMAF suitable for cancer. Contact the lab for more information.
GcMAF injectable is no longer available for purchase. An explanation can be found at GOV.UK, though there is controversy regarding the statements made in this report. GcMAF Injectable was Approximately $900 for 2.2mL. GOleic was Approximately $700 per vial/dropper
GcMAF Autism Facebook Group